When is the best time to go to Murex Lakes?

The best time to visit Murex Lakes is during the dry season, from November to April, when the weather is consistently pleasant and ideal for outdoor activities. During these months, the humidity is lower, and there's less chance of rain, making it great for exploring the natural beauty of the area. Temperatures are usually warm but comfortable, averaging around 20-25°C (68-77°F). This is an excellent time for couples looking to enjoy the region's scenic trails or water-based excursions without the discomfort of scorching heat or heavy downpours. The shoulder months of May and October can also be good options, offering a balance of good weather and fewer crowds. While there's a slightly higher chance of rain or humidity, you'll often find better value on accommodation and a more relaxed pace.

Can I cancel my hotel reservation on Expedia?

Many Expedia hotel reservations are refundable, provided that you cancel before the hotel’s cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Murex Lakes hotel for you.

How much is the nightly rate at a Murex Lakes hotel?

Hotel prices in Murex Lakes often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

10 Best Hotels in Murex Lakes, Sanibel for 2026

An aerial view of a coastal area with a bridge connecting two land masses, a beach, and a clear blue sky.

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Our top choices for Murex Lakes hotels

1. Island Inn

West End, 0.8 km from Murex Lakes

Nicole

CA $315 total

includes taxes & fees

Sep 21 - Sep 22

On the beach, white sand, snorkeling, surfing

2. Shalimar Beach Resort

West End, 1.5 km from Murex Lakes

PATRICIA

CA $349 total

includes taxes & fees

Sep 21 - Sep 22

On the beach, sun loungers, beach towels

3. Sanibel Island Beach Resort

Mid Island, 5.3 km from Murex Lakes

Rogelio

CA $318 total

includes taxes & fees

Oct 5 - Oct 6

4. Residence Inn by Marriott Fort Myers Sanibel

14.1 km from Murex Lakes

jennifer

CA $134 total

includes taxes & fees

Sep 21 - Sep 22

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

14.7 km from Murex Lakes

Jorge

CA $111 total

includes taxes & fees

Sep 28 - Sep 29

In-room safe, blackout drapes, iron/ironing board, cribs (surcharge)

6. Casa Ybel Resort

Ybel, 3 km from Murex Lakes

Karen Elizabeth

CA $397 total

includes taxes & fees

Sep 21 - Sep 22

7. The Anchor Inn

Mid Island, 5.4 km from Murex Lakes

Jamie

CA $241 total

includes taxes & fees

Oct 8 - Oct 9

8. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

17.6 km from Murex Lakes

Kenton Sean

CA $148 total

includes taxes & fees

Oct 18 - Oct 19

9. THE Palmview AND Sandpiper Inns

Mid Island, 5.5 km from Murex Lakes

JACQUELINE

CA $307 total

includes taxes & fees

Oct 12 - Oct 13

10. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

17.4 km from Murex Lakes

Jason

CA $120 total

includes taxes & fees

Sep 28 - Sep 29

Deluxe Suite (Second Floor Only) | Terrace/patio

11. Off the Charts Inn & Out Island Resort

8.1 km from Murex Lakes

Lisa

CA $242 total

includes taxes & fees

Oct 20 - Oct 21

12. Kona Kai Motel

Mid Island, 4.7 km from Murex Lakes

Presley

CA $259 total

includes taxes & fees

Sep 21 - Sep 22

13. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

15.6 km from Murex Lakes

Jennifer

CA $129 total

includes taxes & fees

Sep 21 - Sep 22

Premium bedding, down comforters, desk, laptop workspace

14. Candlewood Suites Fort Myers Sanibel Gateway by IHG

20 km from Murex Lakes

John

CA $81 total

includes taxes & fees

Sep 27 - Sep 28

15. The Lighthouse Resort Inn & Suites

14.7 km from Murex Lakes

Sherrie

CA $169 total

includes taxes & fees

Sep 30 - Oct 1

Floating Coconut Cottage Houseboat | Terrace/patio

16. Latitude 26 Waterfront Resort & Marina

16.2 km from Murex Lakes

Sebastian

CA $138 total

includes taxes & fees

Sep 21 - Sep 22

17. Marriott Sanibel Harbour Resort & Spa

10.9 km from Murex Lakes

Charles

CA $397 total

includes taxes & fees

Oct 4 - Oct 5

Premium Cottage, Lanai, Garden View | Living area

18. Driftwood Inn

Mid Island, 5.4 km from Murex Lakes

Maureen

CA $661 total

includes taxes & fees

Sep 23 - Sep 24

In-room safe, desk, laptop workspace, blackout drapes

19. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

21.2 km from Murex Lakes

john

CA $161 total

includes taxes & fees

Oct 4 - Oct 5

20. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

20.2 km from Murex Lakes

Taylor

CA $144 total

includes taxes & fees

Sep 27 - Sep 28

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Where to stay in Murex Lakes

Find the best Murex Lakes areas and neighborhoods for the activities you enjoy most.

A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

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West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

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East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

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A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Sanibel Island Golf Club and Periwinkle Way are top sights worth seeing.

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A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

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Top Murex Lakes Hotel Reviews

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

10/10 Excellent

"Breakfast was Awesome, room is clean as a whistle 😁 Staff is Awesome 👍 I will be back"

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

10/10 Excellent

"A wonderful stay. Solo female traveler here and I felt safe. Room was clean, bed was clean and comfortable. Bathroom was clean with lots of towels. Check in was great-Lyza was wonderful. Walmart, Dollar Tree and ABC store close by. About equal distance between FT Myers Beach and Sanible which worked out perfectly. My only negative was the pool area. Needs an cleaning and aome new furniture. Breakfast options seemed quite good to me-scrambled eggs, bacon, sausage, biscuits, gravy, cereal, pastries, all types of dairy and non dairy, juice, yogurt...looked great! I'll be back!!"

Margaritaville Beach Resort Fort Myers

8/10 Good

"The staff was excellent. Check-in process with Faith, as the person helping us, was awesome. The property was well maintained. However, we had issues with our AC in our room. They did send someone and he worked on it for about an hour. It was just a little inconvenient. Valais parking is the only option available. It’s an additional $35 per night. Not having access to my vehicle without going through valet was a pain."

Pink Shell Beach Resort and Marina

10/10 Excellent

"Property was well maintained….. clean, pleasant, so many amenities. Breakfast was exceptional. Poolside service, room service. They did not miss anything! New mattress in our unit and all of the personnel were friendly, helpful and efficient! I honestly can not think of one negative comment. So thankful they made a great comeback and I hope to return soon!"

Hotels in Murex Lakes, Sanibel

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Murex Lakes hotels

1. Island Inn

2. Shalimar Beach Resort

3. Sanibel Island Beach Resort

4. Residence Inn by Marriott Fort Myers Sanibel

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

6. Casa Ybel Resort

7. The Anchor Inn

8. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

9. THE Palmview AND Sandpiper Inns

10. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

11. Off the Charts Inn & Out Island Resort

12. Kona Kai Motel

13. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

14. Candlewood Suites Fort Myers Sanibel Gateway by IHG

15. The Lighthouse Resort Inn & Suites

16. Latitude 26 Waterfront Resort & Marina

17. Marriott Sanibel Harbour Resort & Spa

18. Driftwood Inn

19. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

20. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Where to stay in Murex Lakes

Mid Island

West End

East End

Beachview Country Club Estates

Gulf Shores

Top Murex Lakes Hotel Reviews

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Frequently asked questions

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