An aerial view of a coastal area with a bridge connecting two land masses, a beach, and a clear blue sky.

Hotels in Murex Lakes, Sanibel

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Murex Lakes hotels

A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

1. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 5.3 km from Murex Lakes
9.2 out of 10, Wonderful, (2,424 reviews)
"Lovely stay. Great staff and relaxing environment."
United States
Victoria
The price is CA $281
CA $353 total
includes taxes & fees
Nov 11 - Nov 12
Sanibel Island Beach Resort
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

2. Island Inn

Island Inn
3.5 star property
West End, 0.8 km from Murex Lakes
9.4 out of 10, Exceptional, (1,168 reviews)
"Great location"
United States
Nicole
The price is CA $309
CA $345 total
includes taxes & fees
Nov 12 - Nov 13
Island Inn
Living area

3. The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 5.4 km from Murex Lakes
10.0 out of 10, Exceptional, (86 reviews)
"The whole place was wonderful."
United States
April
The price is CA $211
CA $257 total
includes taxes & fees
Nov 15 - Nov 16
The Anchor Inn
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

4. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
14.7 km from Murex Lakes
8.2 out of 10, Very good, (1,404 reviews)
"The staff was very helpful during my stay."
United States
Samantha
The price is CA $119
CA $132 total
includes taxes & fees
Nov 25 - Nov 26
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

5. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 3 km from Murex Lakes
8.8 out of 10, Excellent, (484 reviews)
"Beautiful grounds, restaurant and bar very nice, good beach access"
Canada
Ronald
The price is CA $366
CA $408 total
includes taxes & fees
Nov 11 - Nov 12
Casa Ybel Resort
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

6. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
14.1 km from Murex Lakes
8.8 out of 10, Excellent, (1,004 reviews)
"Loved the balcony view, breakfast spread, hot tub and heated pool."
United States
Lora
The price is CA $144
CA $161 total
includes taxes & fees
Nov 15 - Nov 16
Residence Inn by Marriott Fort Myers Sanibel
A resort with multiple buildings featuring blue roofs, a beach, and a clear view of the ocean.

7. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 1.5 km from Murex Lakes
9.8 out of 10, Exceptional, (110 reviews)
"Room was big and clean. Right on beach and nice pool area and chairs."
United States
JOHN
The price is CA $443
CA $494 total
includes taxes & fees
Nov 15 - Nov 16
Shalimar Beach Resort
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

8. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
10.9 km from Murex Lakes
8.6 out of 10, Excellent, (1,003 reviews)
"I love everything about this hotel"
United States
Yunior
The price is CA $315
CA $401 total
includes taxes & fees
Nov 23 - Nov 24
Marriott Sanibel Harbour Resort & Spa
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

9. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.1 km from Murex Lakes
9.6 out of 10, Exceptional, (165 reviews)
"Very good on everything I love the location"
United States
George
The price is CA $212
CA $284 total
includes taxes & fees
Dec 7 - Dec 8
Off the Charts Inn & Out Island Resort
A balcony with a table and chairs, large windows, and a view of the sea.

10. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
15.7 km from Murex Lakes
9.0 out of 10, Wonderful, (1,003 reviews)
"Very clean and nice place!"
United States
Charles
The price is CA $207
CA $293 total
includes taxes & fees
Nov 16 - Nov 17
The Westin Cape Coral Resort At Marina Village
A balcony with wicker furniture, a view of a beach, and a clear sky.

11. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
14.9 km from Murex Lakes
8.8 out of 10, Excellent, (2,190 reviews)
"Excellent location"
United States
yeny
The price is CA $193
CA $247 total
includes taxes & fees
Dec 7 - Dec 8
Lani Kai Beachfront Resort
A large, clear swimming pool with multiple lounge areas and palm trees.

12. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
14.7 km from Murex Lakes
9.0 out of 10, Wonderful, (2,752 reviews)
"Everything about the resort was excellent"
United States
Lance
The price is CA $253
CA $353 total
includes taxes & fees
Nov 29 - Nov 30
Margaritaville Beach Resort Fort Myers
A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

13. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
17.4 km from Murex Lakes
8.8 out of 10, Excellent, (1,007 reviews)
"I enjoyed my stay - peaceful, wonderful staff & great location"
United States
Melanie
The price is CA $136
CA $152 total
includes taxes & fees
Nov 17 - Nov 18
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

14. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
17.6 km from Murex Lakes
9.2 out of 10, Wonderful, (1,005 reviews)
"Clean Hotel! Convenient for one night stay, close to airport and beaches."
United States
Kimberly
The price is CA $136
CA $151 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.

15. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
15.6 km from Murex Lakes
9.0 out of 10, Wonderful, (1,003 reviews)
"This place was quiet and very clean, we were able to do kayaking & there's a lot of places to eat around. 3-5min from the beaches, shopping & restaurants."
United States
Maria
The price is CA $133
CA $149 total
includes taxes & fees
Nov 11 - Nov 12
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a stone archway.

16. The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
14.7 km from Murex Lakes
8.6 out of 10, Excellent, (1,855 reviews)
"excellent place to stay"
United States
Shayne
The price is CA $114
CA $155 total
includes taxes & fees
Nov 15 - Nov 16
The Lighthouse Resort Inn & Suites
A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

17. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 4.8 km from Murex Lakes
8.6 out of 10, Excellent, (2,720 reviews)
"Great trip, beautiful island and great location!"
United States
Jeremy
The price is CA $473
CA $621 total
includes taxes & fees
Dec 10 - Dec 11
Sundial Beach Resort & Spa
A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

18. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 6.3 km from Murex Lakes
9.2 out of 10, Wonderful, (1,003 reviews)
"Staff was amazingly friendly"
United States
Tamara
The price is CA $411
CA $548 total
includes taxes & fees
Dec 10 - Dec 11
Sanibel Inn
An outdoor patio area with a fire pit table, wicker furniture, and a white fence in the background.

19. Tarpon Tale Inn

Tarpon Tale Inn
3.0 star property
East End, 7.9 km from Murex Lakes
9.6 out of 10, Exceptional, (413 reviews)
"Makes you feel at home. Impeccably kept. Joe and Maureen give attention to details and think of guest convenience and hospitality. Excellent location. Steps from beach and little stores. Sanibel is gorgeous and chill, and so is Tarpon Tales Inn."
United States
Marianella
The price is CA $316
CA $353 total
includes taxes & fees
Nov 16 - Nov 17
Tarpon Tale Inn
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

20. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
14.2 km from Murex Lakes
9.4 out of 10, Exceptional, (1,004 reviews)
"Convenient location, friendly staff and clean rooms."
United States
Stacy
The price is CA $306
CA $341 total
includes taxes & fees
Nov 29 - Nov 30
Best Western Plus Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare top hotels in Murex Lakes

A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

Sanibel Island Beach Resort

3.0 star property
Mid Island, 5.3 km from Murex Lakes
View
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

Island Inn

3.5 star property
West End, 0.8 km from Murex Lakes
View
Living area

The Anchor Inn

2.0 star property
Mid Island, 5.4 km from Murex Lakes
View
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

3.0 star property
14.7 km from Murex Lakes
View
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

Casa Ybel Resort

2.5 star property
Ybel, 3 km from Murex Lakes
View
9.2
Wonderful
2,424 reviews
9.4
Exceptional
1,168 reviews
10.0
Exceptional
86 reviews
8.2
Very good
1,404 reviews
8.8
Excellent
484 reviews
The price is CA $281
CA $353 total
includes taxes & fees
Nov 11 - Nov 12
The price is CA $309
CA $345 total
includes taxes & fees
Nov 12 - Nov 13
The price is CA $211
CA $257 total
includes taxes & fees
Nov 15 - Nov 16
The price is CA $119
CA $132 total
includes taxes & fees
Nov 25 - Nov 26
The price is CA $366
CA $408 total
includes taxes & fees
Nov 11 - Nov 12
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • Yes, Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • No Pet-friendly
  • Yes, WiFi included
  • Yes, Parking

Where to stay in Murex Lakes

Find the best Murex Lakes areas and neighborhoods for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.
A coastal scene with a lighthouse, beach, and ocean.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.
A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.
A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Sanctuary

While Sanctuary might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Blind Pass Beach and Turner Beach.

Top Murex Lakes Hotel Reviews

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

8/10 Good
"Great location to get the full Fort Myers experience. If you’re a light sleeper, this isn’t the place for you. Band plays on ground floor. One elevator takes a little while so be patient. Beds were comfortable. View was amazing! Would stay here again."
Lindsay 2-night trip
Posted 15 hours ago
Lani Kai Beachfront Resort

Frequently asked questions

When is the best time to go to Murex Lakes?
The best time to visit Murex Lakes is during the dry season, from November to April, when the weather is consistently pleasant and ideal for outdoor activities.

During these months, the humidity is lower, and there's less chance of rain, making it great for exploring the natural beauty of the area. Temperatures are usually warm but comfortable, averaging around 20-25°C (68-77°F). This is an excellent time for couples looking to enjoy the region's scenic trails or water-based excursions without the discomfort of scorching heat or heavy downpours.

The shoulder months of May and October can also be good options, offering a balance of good weather and fewer crowds. While there's a slightly higher chance of rain or humidity, you'll often find better value on accommodation and a more relaxed pace.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Murex Lakes hotel for you.
How much is the nightly rate at a Murex Lakes hotel?
Hotel prices in Murex Lakes often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia